Retinol Research Today is a free monthly online journal that collates and summarizes the latest research about Retinol, including details on vitamin a, uses, wrinkle treatment, anti-aging.

Biological activities of retinoidal gamma-hydroxybutenolides in cancer cell apoptosis and differentiation.

Yamano Y, Mizuguchi Y, Fujita Y, Yoshida M, Ito M, Nakagawa K, Okano T

Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada, Kobe 658-8558, Japan. y-yamano@kobepharma-u.ac.jp

Retinoidal gamma-hydroxybutenolides 2a-d having various lengths of conjugated double bond were prepared in three steps from the corresponding aldehyde 4. Their biological activities were then measured. Of these compounds, only compound 2c possessing a structure similar to that of retinoic acid showed differentiation-inducing activity and very strong apoptosis-inducing activity in HL-60 cells.

Published 26 September 2005 in Bioorg Med Chem, 13(21): 6002-8.
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